BDBM50163776 CHEMBL3799742

SMILES: Cn1cc(cn1)-c1ccc(cc1)-c1cncc(Cl)c1N1CCC2(CNC(=O)O2)CC1

InChI Key: InChIKey=ORKBDPRQJKIQTC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50163776   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50163776 (CHEMBL3799742) Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc(Cl)c1N1CCC2(CNC(=O)O2)CC1 Show InChI InChI=1S/C22H22ClN5O2/c1-27-13-17(10-26-27)15-2-4-16(5-3-15)18-11-24-12-19(23)20(18)28-8-6-22(7-9-28)14-25-21(29)30-22/h2-5,10-13H,6-9,14H2,1H3,(H,25,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assay				J Med Chem 59: 1078-101 (2016) BindingDB Entry DOI: 10.7270/Q29025P6
					More data for this Ligand-Target Pair