BDBM50163835 CHEMBL3799073

SMILES: Cn1ncc2cc(ccc12)-c1cnc(N)c(Cl)c1N1CCC2(CNC(=O)O2)CC1

InChI Key: InChIKey=UYMBYVWSBPECIF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50163835   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50163835 (CHEMBL3799073) Show SMILES Cn1ncc2cc(ccc12)-c1cnc(N)c(Cl)c1N1CCC2(CNC(=O)O2)CC1 Show InChI InChI=1S/C20H21ClN6O2/c1-26-15-3-2-12(8-13(15)9-25-26)14-10-23-18(22)16(21)17(14)27-6-4-20(5-7-27)11-24-19(28)29-20/h2-3,8-10H,4-7,11H2,1H3,(H2,22,23)(H,24,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assay				J Med Chem 59: 1078-101 (2016) BindingDB Entry DOI: 10.7270/Q29025P6
					More data for this Ligand-Target Pair