BDBM50163925 5-{(S)-3-(4-Chloro-phenyl)-4-[(R)-1-(4-chloro-phenyl)-ethyl]-2,5-dioxo-7-phenyl-2,3,4,5-tetrahydro-[1,4]diazepin-1-yl}-pentanoic acid::CHEMBL360540

SMILES: C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCCCC(O)=O)C(=CC1=O)c1ccccc1)c1ccc(Cl)cc1

InChI Key: InChIKey=BHHGNJQROMKDLQ-OLILMLBXSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50163925   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM50163925 (5-{(S)-3-(4-Chloro-phenyl)-4-[(R)-1-(4-chloro-phen...) Show SMILES C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCCCC(O)=O)C(=CC1=O)c1ccccc1)c1ccc(Cl)cc1 |c:22| Show InChI InChI=1S/C30H28Cl2N2O4/c1-20(21-10-14-24(31)15-11-21)34-27(35)19-26(22-7-3-2-4-8-22)33(18-6-5-9-28(36)37)30(38)29(34)23-12-16-25(32)17-13-23/h2-4,7-8,10-17,19-20,29H,5-6,9,18H2,1H3,(H,36,37)/t20-,29+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity between MDM2 and p53 protein in fluorescence peptide assay				Bioorg Med Chem Lett 15: 1857-61 (2005) Article DOI: 10.1016/j.bmcl.2005.02.018 BindingDB Entry DOI: 10.7270/Q21G0KRN
					More data for this Ligand-Target Pair