BDBM50163926 (E)-N-[(S)-Carbamoyl-(4-chloro-phenyl)-methyl]-N-[(R)-1-(4-chloro-phenyl)-ethyl]-3-phenyl-acrylamide::CHEMBL182051
SMILES: C[C@@H](N([C@H](C(N)=O)c1ccc(Cl)cc1)C(=O)\C=C\c1ccccc1)c1ccc(Cl)cc1
InChI Key: InChIKey=YGZKZLOWLJRGSJ-YFULZTQESA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MDM2-MDMX (Homo sapiens (Human)) | BDBM50163926 ((E)-N-[(S)-Carbamoyl-(4-chloro-phenyl)-methyl]-N-[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Binding affinity between MDM2 and p53 protein in fluorescence peptide assay | Bioorg Med Chem Lett 15: 1857-61 (2005) Article DOI: 10.1016/j.bmcl.2005.02.018 BindingDB Entry DOI: 10.7270/Q21G0KRN | |||||||||||
More data for this Ligand-Target Pair |