BDBM50164028 CHEMBL182564::N-[2,2'']Bithiophenyl-5-ylmethyl-2,3-dimethyl-N''-(2''-sulfamoyl-biphenyl-4-ylmethyl)-succinamide

SMILES: CC(C(C)C(=O)NCc1ccc(cc1)-c1ccccc1S(N)(=O)=O)C(=O)NCc1ccc(s1)-c1cccs1

InChI Key: InChIKey=GERHTVDUMMAGEB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164028   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50164028 (CHEMBL182564 | N-[2,2'']Bithiophenyl-5-ylmethyl-2,...) Show SMILES CC(C(C)C(=O)NCc1ccc(cc1)-c1ccccc1S(N)(=O)=O)C(=O)NCc1ccc(s1)-c1cccs1 Show InChI InChI=1S/C28H29N3O4S3/c1-18(19(2)28(33)31-17-22-13-14-25(37-22)24-7-5-15-36-24)27(32)30-16-20-9-11-21(12-10-20)23-6-3-4-8-26(23)38(29,34)35/h3-15,18-19H,16-17H2,1-2H3,(H,30,32)(H,31,33)(H2,29,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory concentration against voltage-gated sodium channel Nav1.7 in voltage-ion-probe-reader (VIPR) assay				Bioorg Med Chem Lett 15: 1901-7 (2005) Article DOI: 10.1016/j.bmcl.2005.02.002 BindingDB Entry DOI: 10.7270/Q2HH6JMD
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