BDBM50164109 3-{4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-phenyl}-propionamide::CHEMBL433559

SMILES: Cn1c2nc(Nc3ccc(CCC(N)=O)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O

InChI Key: InChIKey=UGJAIFQOZMLOAH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164109   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50164109 (3-{4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-d...) Show SMILES Cn1c2nc(Nc3ccc(CCC(N)=O)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(2.93,-3.94,;2.93,-2.39,;1.57,-1.62,;.24,-2.42,;-1.09,-1.64,;-2.42,-2.42,;-3.76,-1.64,;-5.09,-2.42,;-6.42,-1.67,;-6.42,-.1,;-7.78,.67,;-7.78,2.21,;-9.11,2.96,;-10.44,2.19,;-9.11,4.5,;-5.09,.67,;-3.76,-.1,;-1.09,-.1,;.24,.69,;1.57,-.08,;2.91,.69,;4.24,-.08,;5.57,.72,;5.57,2.24,;4.22,3.01,;6.88,3.03,;8.24,2.26,;8.24,.72,;6.91,-.05,;6.93,-1.6,;4.26,-1.62,;5.6,-2.39,)| Show InChI InChI=1S/C23H19Cl2N5O2/c1-30-21-14(11-16(22(30)32)20-17(24)3-2-4-18(20)25)12-27-23(29-21)28-15-8-5-13(6-9-15)7-10-19(26)31/h2-6,8-9,11-12H,7,10H2,1H3,(H2,26,31)(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of checkpoint kinase Wee1				Bioorg Med Chem Lett 15: 1931-5 (2005) Article DOI: 10.1016/j.bmcl.2005.01.079 BindingDB Entry DOI: 10.7270/Q280524M
					More data for this Ligand-Target Pair