BDBM50164113 2-{4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-phenoxy}-acetamide::CHEMBL369296

SMILES: Cn1c2nc(Nc3ccc(OCC(N)=O)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O

InChI Key: InChIKey=FAUNKZCVIDAFIW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164113   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50164113 (2-{4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-d...) Show SMILES Cn1c2nc(Nc3ccc(OCC(N)=O)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(2.92,-3.94,;2.92,-2.4,;1.59,-1.63,;.24,-2.4,;-1.09,-1.63,;-2.42,-2.41,;-3.75,-1.64,;-5.08,-2.43,;-6.41,-1.66,;-6.41,-.12,;-7.76,.65,;-7.76,2.19,;-9.09,2.96,;-10.42,2.19,;-9.09,4.5,;-5.08,.67,;-3.75,-.1,;-1.09,-.09,;.24,.68,;1.59,-.09,;2.9,.69,;4.25,-.05,;5.56,.7,;5.56,2.24,;4.21,2.99,;6.88,3.01,;8.22,2.26,;8.24,.72,;6.91,-.05,;6.91,-1.61,;4.25,-1.62,;5.58,-2.38,)| Show InChI InChI=1S/C22H17Cl2N5O3/c1-29-20-12(9-15(21(29)31)19-16(23)3-2-4-17(19)24)10-26-22(28-20)27-13-5-7-14(8-6-13)32-11-18(25)30/h2-10H,11H2,1H3,(H2,25,30)(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of checkpoint kinase Wee1				Bioorg Med Chem Lett 15: 1931-5 (2005) Article DOI: 10.1016/j.bmcl.2005.01.079 BindingDB Entry DOI: 10.7270/Q280524M
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