BDBM50164116 8-Methyl-2-phenylamino-6-(2,3,6-trichloro-phenyl)-8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL360225

SMILES: Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)ccc(Cl)c2Cl)c1=O

InChI Key: InChIKey=ISRHZWDHJNUJFX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164116   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50164116 (8-Methyl-2-phenylamino-6-(2,3,6-trichloro-phenyl)-...) Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)ccc(Cl)c2Cl)c1=O |(1.11,-3.66,;1.11,-2.13,;-.23,-1.34,;-1.58,-2.13,;-2.91,-1.34,;-4.25,-2.14,;-5.58,-1.36,;-6.91,-2.14,;-8.25,-1.38,;-8.25,.18,;-6.91,.95,;-5.58,.18,;-2.91,.19,;-1.58,.97,;-.23,.19,;1.08,.97,;2.43,.23,;3.75,.98,;5.1,.23,;5.11,-1.32,;6.43,1,;6.41,2.54,;5.08,3.3,;5.06,4.86,;3.75,2.54,;2.39,3.29,;2.44,-1.34,;3.77,-2.09,)| Show InChI InChI=1S/C20H13Cl3N4O/c1-27-18-11(10-24-20(26-18)25-12-5-3-2-4-6-12)9-13(19(27)28)16-14(21)7-8-15(22)17(16)23/h2-10H,1H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of checkpoint kinase Wee1				Bioorg Med Chem Lett 15: 1931-5 (2005) Article DOI: 10.1016/j.bmcl.2005.01.079 BindingDB Entry DOI: 10.7270/Q280524M
					More data for this Ligand-Target Pair