BDBM50164121 2-{4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-phenyl}-acetamide::CHEMBL178758

SMILES: Cn1c2nc(Nc3ccc(CC(N)=O)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O

InChI Key: InChIKey=URFCMVULTIAJNO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164121   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50164121 (2-{4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-d...) Show SMILES Cn1c2nc(Nc3ccc(CC(N)=O)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(2.5,-3.81,;2.5,-2.27,;1.17,-1.5,;-.18,-2.29,;-1.51,-1.52,;-2.84,-2.29,;-4.17,-1.52,;-5.5,-2.29,;-6.83,-1.55,;-6.83,.02,;-8.17,.79,;-8.18,2.33,;-6.84,3.1,;-9.51,3.07,;-5.5,.79,;-4.17,.02,;-1.51,.02,;-.18,.81,;1.17,.04,;2.48,.81,;3.83,.04,;5.14,.83,;5.14,2.36,;3.79,3.12,;6.46,3.14,;7.8,2.37,;7.82,.83,;6.49,.06,;6.49,-1.48,;3.83,-1.5,;5.16,-2.27,)| Show InChI InChI=1S/C22H17Cl2N5O2/c1-29-20-13(10-15(21(29)31)19-16(23)3-2-4-17(19)24)11-26-22(28-20)27-14-7-5-12(6-8-14)9-18(25)30/h2-8,10-11H,9H2,1H3,(H2,25,30)(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of checkpoint kinase Wee1				Bioorg Med Chem Lett 15: 1931-5 (2005) Article DOI: 10.1016/j.bmcl.2005.01.079 BindingDB Entry DOI: 10.7270/Q280524M
					More data for this Ligand-Target Pair