BDBM50164128 6-(2,6-Dichloro-3,5-dihydroxy-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL361347

SMILES: Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)c(O)cc(O)c2Cl)c1=O

InChI Key: InChIKey=BAMKXISZMCXXPK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164128   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50164128 (6-(2,6-Dichloro-3,5-dihydroxy-phenyl)-8-methyl-2-p...) Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)c(O)cc(O)c2Cl)c1=O |(.83,-3.66,;.83,-2.13,;-.51,-1.34,;-1.84,-2.14,;-3.17,-1.36,;-4.5,-2.15,;-5.86,-1.38,;-5.84,.16,;-7.19,.94,;-8.53,.16,;-8.5,-1.39,;-7.17,-2.15,;-3.17,.18,;-1.84,.96,;-.51,.19,;.82,.96,;2.16,.2,;3.49,.98,;4.82,.21,;4.82,-1.33,;6.16,.98,;7.49,.23,;6.16,2.53,;4.8,3.3,;4.78,4.84,;3.47,2.52,;2.13,3.27,;2.16,-1.34,;3.52,-2.11,)| Show InChI InChI=1S/C20H14Cl2N4O3/c1-26-18-10(9-23-20(25-18)24-11-5-3-2-4-6-11)7-12(19(26)29)15-16(21)13(27)8-14(28)17(15)22/h2-9,27-28H,1H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of checkpoint kinase Wee1				Bioorg Med Chem Lett 15: 1931-5 (2005) Article DOI: 10.1016/j.bmcl.2005.01.079 BindingDB Entry DOI: 10.7270/Q280524M
					More data for this Ligand-Target Pair