BDBM50164137 6-(2,6-Dichloro-4-methoxy-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL360672

SMILES: COc1cc(Cl)c(c(Cl)c1)-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O

InChI Key: InChIKey=PBCKOKJYNHZZCL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164137   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50164137 (6-(2,6-Dichloro-4-methoxy-phenyl)-8-methyl-2-pheny...) Show SMILES COc1cc(Cl)c(c(Cl)c1)-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O |(8.66,2.52,;7.33,3.29,;6,2.5,;4.65,3.27,;3.32,2.49,;1.99,3.24,;3.34,.96,;4.67,.19,;4.67,-1.35,;6,.96,;2.01,.18,;.68,.93,;-.65,.16,;-1.98,.93,;-3.31,.16,;-3.31,-1.38,;-4.64,-2.17,;-5.99,-1.4,;-7.3,-2.17,;-8.63,-1.41,;-8.65,.14,;-7.32,.91,;-5.97,.14,;-1.98,-2.15,;-.65,-1.38,;.68,-2.15,;.68,-3.69,;2.01,-1.38,;3.37,-2.13,)| Show InChI InChI=1S/C21H16Cl2N4O2/c1-27-19-12(11-24-21(26-19)25-13-6-4-3-5-7-13)8-15(20(27)28)18-16(22)9-14(29-2)10-17(18)23/h3-11H,1-2H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of checkpoint kinase Wee1				Bioorg Med Chem Lett 15: 1931-5 (2005) Article DOI: 10.1016/j.bmcl.2005.01.079 BindingDB Entry DOI: 10.7270/Q280524M
					More data for this Ligand-Target Pair