BDBM50164142 6-(2,6-Difluoro-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL425873

SMILES: Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(F)cccc2F)c1=O

InChI Key: InChIKey=UWVTXHPSMSGHCL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164142   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50164142 (6-(2,6-Difluoro-phenyl)-8-methyl-2-phenylamino-8H-...) Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(F)cccc2F)c1=O |(1.29,-3.48,;1.29,-1.94,;-.06,-1.17,;-1.39,-1.94,;-2.72,-1.17,;-4.05,-1.94,;-5.38,-1.17,;-5.38,.37,;-6.71,1.14,;-8.04,.34,;-8.03,-1.2,;-6.71,-1.97,;-2.72,.37,;-1.39,1.14,;-.06,.37,;1.27,1.16,;2.61,.39,;3.93,1.16,;5.26,.4,;5.28,-1.15,;6.59,1.18,;6.59,2.72,;5.23,3.48,;3.93,2.7,;2.57,3.45,;2.62,-1.15,;3.95,-1.92,)| Show InChI InChI=1S/C20H14F2N4O/c1-26-18-12(11-23-20(25-18)24-13-6-3-2-4-7-13)10-14(19(26)27)17-15(21)8-5-9-16(17)22/h2-11H,1H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of checkpoint kinase Wee1				Bioorg Med Chem Lett 15: 1931-5 (2005) Article DOI: 10.1016/j.bmcl.2005.01.079 BindingDB Entry DOI: 10.7270/Q280524M
					More data for this Ligand-Target Pair