BDBM50164143 2-[4-(2-Diethylamino-ethoxy)-phenylamino]-6-(2,6-dimethyl-phenyl)-5,8-dimethyl-8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL180821

SMILES: CCN(CC)CCOc1ccc(Nc2ncc3c(C)c(-c4c(C)cccc4C)c(=O)n(C)c3n2)cc1

InChI Key: InChIKey=SCXAQLWEFWQGGR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164143   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50164143 (2-[4-(2-Diethylamino-ethoxy)-phenylamino]-6-(2,6-d...) Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3c(C)c(-c4c(C)cccc4C)c(=O)n(C)c3n2)cc1 |(-9.79,6.13,;-9.79,4.6,;-8.46,3.83,;-7.13,4.6,;-7.13,6.15,;-8.44,2.28,;-7.11,1.53,;-7.11,-.01,;-5.78,-.78,;-4.45,,;-3.1,-.78,;-3.12,-2.31,;-1.77,-3.08,;-.44,-2.31,;-.44,-.75,;.89,,;2.22,-.75,;3.55,.02,;3.53,1.56,;4.88,-.75,;6.21,.04,;6.19,1.56,;4.85,2.33,;7.52,2.35,;8.87,1.59,;8.87,.04,;7.54,-.75,;7.54,-2.27,;4.88,-2.29,;6.23,-3.06,;3.55,-3.06,;3.55,-4.6,;2.22,-2.31,;.89,-3.08,;-4.43,-3.09,;-5.76,-2.33,)| Show InChI InChI=1S/C29H35N5O2/c1-7-34(8-2)16-17-36-23-14-12-22(13-15-23)31-29-30-18-24-21(5)26(28(35)33(6)27(24)32-29)25-19(3)10-9-11-20(25)4/h9-15,18H,7-8,16-17H2,1-6H3,(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of checkpoint kinase Wee1				Bioorg Med Chem Lett 15: 1931-5 (2005) Article DOI: 10.1016/j.bmcl.2005.01.079 BindingDB Entry DOI: 10.7270/Q280524M
					More data for this Ligand-Target Pair