BDBM50164152 6-(2,6-Dimethyl-phenyl)-5,8-dimethyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL180794

SMILES: Cc1cccc(C)c1-c1c(C)c2cnc(Nc3ccccc3)nc2n(C)c1=O

InChI Key: InChIKey=JQROFTYKPOEECE-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164152   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50164152 (6-(2,6-Dimethyl-phenyl)-5,8-dimethyl-2-phenylamino...) Show SMILES Cc1cccc(C)c1-c1c(C)c2cnc(Nc3ccccc3)nc2n(C)c1=O |(5.23,-1.24,;5.23,.3,;6.56,1.09,;6.54,2.63,;5.2,3.38,;3.88,2.61,;2.53,3.35,;3.88,1.07,;2.57,.3,;1.22,1.07,;1.22,2.61,;-.09,.27,;-1.42,1.05,;-2.77,.27,;-2.77,-1.27,;-4.1,-2.04,;-5.44,-1.27,;-6.76,-2.06,;-8.09,-1.29,;-8.11,.25,;-6.76,1.04,;-5.41,.27,;-1.42,-2.04,;-.09,-1.27,;1.24,-2.04,;1.24,-3.58,;2.57,-1.24,;3.92,-2.01,)| Show InChI InChI=1S/C23H22N4O/c1-14-9-8-10-15(2)19(14)20-16(3)18-13-24-23(25-17-11-6-5-7-12-17)26-21(18)27(4)22(20)28/h5-13H,1-4H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of checkpoint kinase Wee1				Bioorg Med Chem Lett 15: 1931-5 (2005) Article DOI: 10.1016/j.bmcl.2005.01.079 BindingDB Entry DOI: 10.7270/Q280524M
					More data for this Ligand-Target Pair