BDBM50164350 6-(4-Chloro-phenyl)-3-{2-[4-(2-chloro-phenyl)-piperazin-1-yl]-ethyl}-1,5-dihydro-pyrrolo[3,2-d]pyrimidine-2,4-dione::CHEMBL191425
SMILES: Clc1ccc(cc1)-c1cc2[nH]c(=O)n(CCN3CCN(CC3)c3ccccc3Cl)c(=O)c2[nH]1
InChI Key: InChIKey=DMQPHRQAXQYLGW-UHFFFAOYSA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(1A) dopamine receptor (RAT) | BDBM50164350 (6-(4-Chloro-phenyl)-3-{2-[4-(2-chloro-phenyl)-pipe...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Catania Curated by ChEMBL | Assay Description Inhibition of [3H]-SCH-23,390 binding to Dopamine receptor D1 from rat striatum | J Med Chem 48: 2420-31 (2005) Article DOI: 10.1021/jm040870h BindingDB Entry DOI: 10.7270/Q2377872 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50164350 (6-(4-Chloro-phenyl)-3-{2-[4-(2-chloro-phenyl)-pipe...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Catania Curated by ChEMBL | Assay Description Displacement of [3H]-8-OH-DPAT from 5HT1A in CRL:CD(SD)BR-COBS rat brain hippocampus after 30 mins by liquid scintillation spectrometry | Bioorg Med Chem 19: 5260-76 (2011) Article DOI: 10.1016/j.bmc.2011.06.043 BindingDB Entry DOI: 10.7270/Q2D50NBD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50164350 (6-(4-Chloro-phenyl)-3-{2-[4-(2-chloro-phenyl)-pipe...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Catania Curated by ChEMBL | Assay Description Inhibtion of [3H]-8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from rat hippocampus | J Med Chem 48: 2420-31 (2005) Article DOI: 10.1021/jm040870h BindingDB Entry DOI: 10.7270/Q2377872 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50164350 (6-(4-Chloro-phenyl)-3-{2-[4-(2-chloro-phenyl)-pipe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Catania Curated by ChEMBL | Assay Description Inhibition of [3H]-spiperone binding to Dopamine receptor D2 from rat striatum | J Med Chem 48: 2420-31 (2005) Article DOI: 10.1021/jm040870h BindingDB Entry DOI: 10.7270/Q2377872 | |||||||||||
More data for this Ligand-Target Pair |