BDBM50164549 (2R,3S)-1-(7-Bromo-phenanthrene-2-carbonyl)-piperazine-2,3-dicarboxylic acid::CHEMBL192866
SMILES: OC(=O)[C@H]1NCCN([C@H]1C(O)=O)C(=O)c1ccc2c(ccc3cc(Br)ccc23)c1
InChI Key: InChIKey=XRYANSHQGSXETP-ZWKOTPCHSA-N
Data: 6 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1 (RAT-Rattus norvegicus (Rat)) | BDBM50164549 ((2R,3S)-1-(7-Bromo-phenanthrene-2-carbonyl)-pipera...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 99.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk Curated by ChEMBL | Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2C expressed in Xeno... | J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1 (RAT-Rattus norvegicus (Rat)) | BDBM50164549 ((2R,3S)-1-(7-Bromo-phenanthrene-2-carbonyl)-pipera...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol Curated by ChEMBL | Assay Description Antagonist activity rat recombinant GluN1/GluN2C receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response by... | J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate [NMDA] receptor subunit epsilon 2/zeta 1 (Rattus norvegicus (Rat)-RAT) | BDBM50164549 ((2R,3S)-1-(7-Bromo-phenanthrene-2-carbonyl)-pipera...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol Curated by ChEMBL | Assay Description Antagonist activity rat recombinant GluN1/GluN2B receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response by... | J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate [NMDA] receptor subunit epsilon 2/zeta 1 (Rattus norvegicus (Rat)-RAT) | BDBM50164549 ((2R,3S)-1-(7-Bromo-phenanthrene-2-carbonyl)-pipera...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk Curated by ChEMBL | Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2B expressed in Xeno... | J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1 (Rattus norvegicus (Rat)-RAT) | BDBM50164549 ((2R,3S)-1-(7-Bromo-phenanthrene-2-carbonyl)-pipera...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol Curated by ChEMBL | Assay Description Antagonist activity at rat recombinant GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate-induced response... | J Med Chem 55: 327-41 (2012) Article DOI: 10.1021/jm201230z BindingDB Entry DOI: 10.7270/Q2TD9XTJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1 (Rattus norvegicus (Rat)-RAT) | BDBM50164549 ((2R,3S)-1-(7-Bromo-phenanthrene-2-carbonyl)-pipera...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk Curated by ChEMBL | Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno... | J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89 | |||||||||||
More data for this Ligand-Target Pair |