Found 4 hits for monomerid = 50165885 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50165885
(CHEMBL3798505)Show SMILES Fc1ccc(NS(=O)(=O)N2CCCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 Show InChI InChI=1S/C21H20F2N8O2S/c22-14-6-7-15(30-34(32,33)31-9-2-1-3-10-31)16(23)18(14)29-20-13(5-4-8-24-20)17-19-21(27-11-25-17)28-12-26-19/h4-8,11-12,30H,1-3,9-10H2,(H,24,29)(H,25,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of wild type B-Raf (unknown origin) assessed as MEK1 phosphorylation using MEK1-Avitag as substrate after 1 hr by HTRF assay |
Bioorg Med Chem 24: 2215-34 (2016)
Article DOI: 10.1016/j.bmc.2016.03.055
BindingDB Entry DOI: 10.7270/Q21C1ZS0 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50165885
(CHEMBL3798505)Show SMILES Fc1ccc(NS(=O)(=O)N2CCCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 Show InChI InChI=1S/C21H20F2N8O2S/c22-14-6-7-15(30-34(32,33)31-9-2-1-3-10-31)16(23)18(14)29-20-13(5-4-8-24-20)17-19-21(27-11-25-17)28-12-26-19/h4-8,11-12,30H,1-3,9-10H2,(H,24,29)(H,25,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant (unknown origin) assessed as MEK1 phosphorylation using MEK1-Avitag as substrate after 1 hr by HTRF assay |
Bioorg Med Chem 24: 2215-34 (2016)
Article DOI: 10.1016/j.bmc.2016.03.055
BindingDB Entry DOI: 10.7270/Q21C1ZS0 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50165885
(CHEMBL3798505)Show SMILES Fc1ccc(NS(=O)(=O)N2CCCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 Show InChI InChI=1S/C21H20F2N8O2S/c22-14-6-7-15(30-34(32,33)31-9-2-1-3-10-31)16(23)18(14)29-20-13(5-4-8-24-20)17-19-21(27-11-25-17)28-12-26-19/h4-8,11-12,30H,1-3,9-10H2,(H,24,29)(H,25,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant in human A375 cells assessed as ERK phosphorylation preincubated for 1 hr by Western blot method |
Bioorg Med Chem 24: 2215-34 (2016)
Article DOI: 10.1016/j.bmc.2016.03.055
BindingDB Entry DOI: 10.7270/Q21C1ZS0 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50165885
(CHEMBL3798505)Show SMILES Fc1ccc(NS(=O)(=O)N2CCCCC2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 Show InChI InChI=1S/C21H20F2N8O2S/c22-14-6-7-15(30-34(32,33)31-9-2-1-3-10-31)16(23)18(14)29-20-13(5-4-8-24-20)17-19-21(27-11-25-17)28-12-26-19/h4-8,11-12,30H,1-3,9-10H2,(H,24,29)(H,25,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.22E+3 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of wild type B-Raf in human MIAPaCa2 cells assessed as reduction in ERK phosphorylation preincubated for 1 hr by Western blot method |
Bioorg Med Chem 24: 2215-34 (2016)
Article DOI: 10.1016/j.bmc.2016.03.055
BindingDB Entry DOI: 10.7270/Q21C1ZS0 |
More data for this
Ligand-Target Pair | |
Search and Browse
