BDBM50166461 3-((R)-2-Amino-2-phenyl-ethyl)-5-(3-ethoxy-2-fluoro-phenyl)-1-(2-fluoro-6-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione::CHEMBL190929

SMILES: CCOc1cccc(c1F)-c1cn(Cc2c(F)cccc2C(F)(F)F)c(=O)n(C[C@H](N)c2ccccc2)c1=O

InChI Key: InChIKey=GVDSXDNAIPJAFW-QHCPKHFHSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50166461   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50166461 (3-((R)-2-Amino-2-phenyl-ethyl)-5-(3-ethoxy-2-fluor...) Show SMILES CCOc1cccc(c1F)-c1cn(Cc2c(F)cccc2C(F)(F)F)c(=O)n(C[C@H](N)c2ccccc2)c1=O Show InChI InChI=1S/C28H24F5N3O3/c1-2-39-24-13-6-10-18(25(24)30)19-14-35(15-20-21(28(31,32)33)11-7-12-22(20)29)27(38)36(26(19)37)16-23(34)17-8-4-3-5-9-17/h3-14,23H,2,15-16,34H2,1H3/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin-releasing hormone receptor (GNRHR) using GnRH peptide as radioligand				Bioorg Med Chem Lett 15: 2519-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.057 BindingDB Entry DOI: 10.7270/Q2M044ZX
					More data for this Ligand-Target Pair