BDBM50166511 3-[2-(3-Fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)-5-isopropyl-6-methyl-3H-pyrimidin-4-one::CHEMBL195711

SMILES: CC(C)c1c(C)nc(-c2ccccc2O)n(CCc2cccc(F)c2)c1=O

InChI Key: InChIKey=KRYJDLCTPNQQMJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50166511   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium-sensing receptor (CaSR) (Homo sapiens (Human))	BDBM50166511 (3-[2-(3-Fluoro-phenyl)-ethyl]-2-(2-hydroxy-phenyl)...) Show SMILES CC(C)c1c(C)nc(-c2ccccc2O)n(CCc2cccc(F)c2)c1=O Show InChI InChI=1S/C22H23FN2O2/c1-14(2)20-15(3)24-21(18-9-4-5-10-19(18)26)25(22(20)27)12-11-16-7-6-8-17(23)13-16/h4-10,13-14,26H,11-12H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
NPS Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory concentration was evaluated for in vitro calcilytic activity against human calcium receptor				Bioorg Med Chem Lett 15: 2537-40 (2005) Article DOI: 10.1016/j.bmcl.2005.03.054 BindingDB Entry DOI: 10.7270/Q26Q1WRQ
					More data for this Ligand-Target Pair