BDBM50166816 3-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-8-methyl-2H-2,4,4b,9-tetraaza-fluoren-1-one::CHEMBL193487

SMILES: CCOc1ccc(cc1-c1nc2c(nc3c(C)cccn23)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1

InChI Key: InChIKey=KLQSJPGBFVWQFD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50166816   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50166816 (3-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...) Show SMILES CCOc1ccc(cc1-c1nc2c(nc3c(C)cccn23)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C23H26N6O4S/c1-4-33-18-8-7-16(34(31,32)28-12-10-27(3)11-13-28)14-17(18)20-25-22-19(23(30)26-20)24-21-15(2)6-5-9-29(21)22/h5-9,14H,4,10-13H2,1-3H3,(H,25,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 5 isolated from human platelets				Bioorg Med Chem Lett 15: 2790-4 (2005) Article DOI: 10.1016/j.bmcl.2005.03.102 BindingDB Entry DOI: 10.7270/Q2JW8FNG
					More data for this Ligand-Target Pair
Phosphodiesterase 6 (Bos taurus-Bos taurus (Bovine))	BDBM50166816 (3-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...) Show SMILES CCOc1ccc(cc1-c1nc2c(nc3c(C)cccn23)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C23H26N6O4S/c1-4-33-18-8-7-16(34(31,32)28-12-10-27(3)11-13-28)14-17(18)20-25-22-19(23(30)26-20)24-21-15(2)6-5-9-29(21)22/h5-9,14H,4,10-13H2,1-3H3,(H,25,26,30)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	472	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 6 isolated from bovine retina				Bioorg Med Chem Lett 15: 2790-4 (2005) Article DOI: 10.1016/j.bmcl.2005.03.102 BindingDB Entry DOI: 10.7270/Q2JW8FNG
					More data for this Ligand-Target Pair