BDBM50167619 (2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(4-methyl-benzyloxy)-benzenesulfonyl]-piperidine-2-carboxylic acid hydroxyamide::CHEMBL191359
SMILES: Cc1ccc(COc2ccc(cc2)S(=O)(=O)N2C[C@H](O)CC(C)(C)[C@@H]2C(=O)NO)cc1
InChI Key: InChIKey=ZXORTEVXPYNWIB-XLIONFOSSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human)) | BDBM50167619 ((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(4-methyl-benz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Groton Laboratories Curated by ChEMBL | Assay Description Inhibitory concentration against TNF-alpha converting enzyme | Bioorg Med Chem Lett 15: 2808-11 (2005) Article DOI: 10.1016/j.bmcl.2005.03.105 BindingDB Entry DOI: 10.7270/Q2BC3Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interstitial collagenase (Homo sapiens (Human)) | BDBM50167619 ((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(4-methyl-benz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 198 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Groton Laboratories Curated by ChEMBL | Assay Description Inhibitory concentration against Matrix metalloproteinase-1 (MMP-1) | Bioorg Med Chem Lett 15: 2808-11 (2005) Article DOI: 10.1016/j.bmcl.2005.03.105 BindingDB Entry DOI: 10.7270/Q2BC3Z24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Collagenase 3 (Homo sapiens (Human)) | BDBM50167619 ((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(4-methyl-benz...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Groton Laboratories Curated by ChEMBL | Assay Description Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13) | Bioorg Med Chem Lett 15: 2808-11 (2005) Article DOI: 10.1016/j.bmcl.2005.03.105 BindingDB Entry DOI: 10.7270/Q2BC3Z24 | |||||||||||
More data for this Ligand-Target Pair |