BDBM50168390 2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino]-N-methoxy-benzamide::CHEMBL192101

SMILES: CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F

InChI Key: InChIKey=OSPKANQURMXUIE-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50168390   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor (Homo sapiens (Human))	BDBM50168390 (2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...) Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation				J Med Chem 48: 3991-4008 (2005) Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50168390 (2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...) Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human fibroblast growth factor receptor 1				J Med Chem 48: 3991-4008 (2005) Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50168390 (2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...) Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)				J Med Chem 48: 3991-4008 (2005) Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor (Homo sapiens (Human))	BDBM50168390 (2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...) Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation				J Med Chem 48: 3991-4008 (2005) Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN
					More data for this Ligand-Target Pair