BDBM50168396 4-(5-Cyclopropylmethoxycarbamoyl-2,4-difluoro-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester::CHEMBL195254

SMILES: CCOC(=O)c1cn2ncnc(Nc3cc(C(=O)NOCC4CC4)c(F)cc3F)c2c1C(C)C

InChI Key: InChIKey=LWLPNORGRWZWTF-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50168396   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50168396 (4-(5-Cyclopropylmethoxycarbamoyl-2,4-difluoro-phen...) Show SMILES CCOC(=O)c1cn2ncnc(Nc3cc(C(=O)NOCC4CC4)c(F)cc3F)c2c1C(C)C Show InChI InChI=1S/C23H25F2N5O4/c1-4-33-23(32)15-9-30-20(19(15)12(2)3)21(26-11-27-30)28-18-7-14(16(24)8-17(18)25)22(31)29-34-10-13-5-6-13/h7-9,11-13H,4-6,10H2,1-3H3,(H,29,31)(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)				J Med Chem 48: 3991-4008 (2005) Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN
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