BDBM50168411 4-(2-Fluoro-5-methoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester::CHEMBL363639

SMILES: CCOC(=O)c1cn2ncnc(Nc3cc(ccc3F)C(=O)NOC)c2c1C(C)C

InChI Key: InChIKey=XLGWCMNWLJXCJW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50168411   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50168411 (4-(2-Fluoro-5-methoxycarbamoyl-phenylamino)-5-isop...) Show SMILES CCOC(=O)c1cn2ncnc(Nc3cc(ccc3F)C(=O)NOC)c2c1C(C)C Show InChI InChI=1S/C20H22FN5O4/c1-5-30-20(28)13-9-26-17(16(13)11(2)3)18(22-10-23-26)24-15-8-12(6-7-14(15)21)19(27)25-29-4/h6-11H,5H2,1-4H3,(H,25,27)(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)				J Med Chem 48: 3991-4008 (2005) Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN
					More data for this Ligand-Target Pair