BDBM50168412 4-(2,4-Difluoro-5-isopropoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester::CHEMBL195845

SMILES: CCOC(=O)c1cn2ncnc(Nc3cc(C(=O)NOC(C)C)c(F)cc3F)c2c1C(C)C

InChI Key: InChIKey=JHEIWNWUGUUWSN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50168412   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50168412 (4-(2,4-Difluoro-5-isopropoxycarbamoyl-phenylamino)...) Show SMILES CCOC(=O)c1cn2ncnc(Nc3cc(C(=O)NOC(C)C)c(F)cc3F)c2c1C(C)C Show InChI InChI=1S/C22H25F2N5O4/c1-6-32-22(31)14-9-29-19(18(14)11(2)3)20(25-10-26-29)27-17-7-13(15(23)8-16(17)24)21(30)28-33-12(4)5/h7-12H,6H2,1-5H3,(H,28,30)(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)				J Med Chem 48: 3991-4008 (2005) Article DOI: 10.1021/jm0501275 BindingDB Entry DOI: 10.7270/Q2KP81QN
					More data for this Ligand-Target Pair