Found 15 hits for monomerid = 50168962 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glutamate receptor ionotropic kainate
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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CHEMBL KEGG PC cid PC sid UniChem
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| Article PubMed
| 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigaci�n Lilly
Curated by ChEMBL
| Assay Description Binding affinity to GluK1 receptor (unknown origin) |
Bioorg Med Chem Lett 23: 6459-62 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.046 BindingDB Entry DOI: 10.7270/Q2862KDB |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic kainate
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigaci�n Lilly
Curated by ChEMBL
| Assay Description Displacement of [3H]ATPA from human Gluk1 receptor |
Bioorg Med Chem Lett 23: 6463-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.045 BindingDB Entry DOI: 10.7270/Q2XS5ZBW |
More data for this Ligand-Target Pair | |
Grik5
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB
UniProtKB/SwissProt
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| Article PubMed
| 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 318: 772-81 (2006)
Article DOI: 10.1124/jpet.106.101428 BindingDB Entry DOI: 10.7270/Q2NP230D |
More data for this Ligand-Target Pair | |
GRIA4
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 318: 772-81 (2006)
Article DOI: 10.1124/jpet.106.101428 BindingDB Entry DOI: 10.7270/Q2NP230D |
More data for this Ligand-Target Pair | |
Glutamate-Kainate 7
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL KEGG PC cid PC sid UniChem
Patents
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 318: 772-81 (2006)
Article DOI: 10.1124/jpet.106.101428 BindingDB Entry DOI: 10.7270/Q2NP230D |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 2
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB
UniProtKB/SwissProt
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CHEMBL KEGG PC cid PC sid UniChem
Patents
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 318: 772-81 (2006)
Article DOI: 10.1124/jpet.106.101428 BindingDB Entry DOI: 10.7270/Q2NP230D |
More data for this Ligand-Target Pair | |
GRIA2
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL KEGG PC cid PC sid UniChem
Patents
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 318: 772-81 (2006)
Article DOI: 10.1124/jpet.106.101428 BindingDB Entry DOI: 10.7270/Q2NP230D |
More data for this Ligand-Target Pair | |
GRIA1
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL KEGG PC cid PC sid UniChem
Patents
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 318: 772-81 (2006)
Article DOI: 10.1124/jpet.106.101428 BindingDB Entry DOI: 10.7270/Q2NP230D |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 2
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB
UniProtKB/SwissProt
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CHEMBL KEGG PC cid PC sid UniChem
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol
Curated by PDSP Ki Database
| |
Nature 402: 297-301 (1999)
Article DOI: 10.1038/46290 BindingDB Entry DOI: 10.7270/Q2ZK5F7K |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 2
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol
Curated by PDSP Ki Database
| |
Nature 402: 297-301 (1999)
Article DOI: 10.1038/46290 BindingDB Entry DOI: 10.7270/Q2ZK5F7K |
More data for this Ligand-Target Pair | |
GRIK1
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB MMDB
KEGG
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Patents
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| Article PubMed
| 1.71E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigación Lilly
Curated by ChEMBL
| Assay Description Inhibition of [3H]-KA binding to iontropic glutamate receptor 5 |
J Med Chem 48: 4200-3 (2005)
Article DOI: 10.1021/jm0491952 BindingDB Entry DOI: 10.7270/Q2HQ3ZDM |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 2
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL KEGG PC cid PC sid UniChem
Patents
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| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigación Lilly
Curated by ChEMBL
| Assay Description Inhibition of [3H]-KA binding to iontropic glutamate receptor 6 |
J Med Chem 48: 4200-3 (2005)
Article DOI: 10.1021/jm0491952 BindingDB Entry DOI: 10.7270/Q2HQ3ZDM |
More data for this Ligand-Target Pair | |
GRIA2
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigación Lilly
Curated by ChEMBL
| Assay Description Inhibition of [3H]-AMPA binding to human GluR2 receptors expressed in HEK 293 cells |
J Med Chem 48: 4200-3 (2005)
Article DOI: 10.1021/jm0491952 BindingDB Entry DOI: 10.7270/Q2HQ3ZDM |
More data for this Ligand-Target Pair | |
Glutamate receptor AMPA 1/2
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 5.53E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigaci�n Lilly
Curated by ChEMBL
| Assay Description Binding affinity to GluA2 receptor (unknown origin) |
Bioorg Med Chem Lett 23: 6459-62 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.046 BindingDB Entry DOI: 10.7270/Q2862KDB |
More data for this Ligand-Target Pair | |
Glutamate receptor AMPA 1/2
(Homo sapiens (Human)) | BDBM50168962
((3S,4aR,6S,8aR)-6-(4-Carboxy-benzyl)-decahydro-iso...)Show SMILES OC(=O)[C@@H]1C[C@H]2C[C@@H](Cc3ccc(cc3)C(O)=O)CC[C@H]2CN1 Show InChI InChI=1S/C18H23NO4/c20-17(21)13-4-1-11(2-5-13)7-12-3-6-14-10-19-16(18(22)23)9-15(14)8-12/h1-2,4-5,12,14-16,19H,3,6-10H2,(H,20,21)(H,22,23)/t12-,14+,15-,16+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 5.53E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigaci�n Lilly
Curated by ChEMBL
| Assay Description Displacement of [3H]AMPA from homomeric recombinant GluA2 receptor (unknown origin) |
Bioorg Med Chem Lett 23: 6463-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.09.045 BindingDB Entry DOI: 10.7270/Q2XS5ZBW |
More data for this Ligand-Target Pair | |