BDBM50168995 (-)-swainsonine::(1S,2R,8R,8aR)-Octahydro-indolizine-1,2,8-triol::1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL::CHEMBL371197::SWAINSONINE

SMILES: O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O

InChI Key: InChIKey=FXUAIOOAOAVCGD-WCTZXXKLSA-N

Data: 4 KI  7 IC50

PDB links: 5 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50168995   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Golgi alpha-mannosidase II (Drosophila melanogaster (Fruit fly))	BDBM50168995 ((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...) Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O |r| Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	3	-11.6	37	n/a	n/a	n/a	n/a	5.75	25
University of Toronto					Assay Description Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...				Chembiochem 11: 673-80 (2010) Article DOI: 10.1002/cbic.200900750 BindingDB Entry DOI: 10.7270/Q2WS8RRM
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform B (Drosophila melanogaster)	BDBM50168995 ((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...) Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O |r| Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Slovak Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of Drosophila melanogaster GM2b by spectrophotometry				Eur J Med Chem 46: 944-52 (2011) Article DOI: 10.1016/j.ejmech.2011.01.012 BindingDB Entry DOI: 10.7270/Q2MS3TQM
					More data for this Ligand-Target Pair
Alpha-1,2-mannosidase, putative (Bacteroides thetaiotaomicron )	BDBM50168995 ((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...) Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O |r| Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Newcastle University Curated by ChEMBL					Assay Description Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3990 assessed as reduction of mannose release using 4NP-mannopyranoside substrate				Nat Chem Biol 6: 125-32 (2010) Article DOI: 10.1038/nchembio.278 BindingDB Entry DOI: 10.7270/Q2ZW1PQB
					More data for this Ligand-Target Pair
Alpha-1,2-mannosidase, putative (Bacteroides thetaiotaomicron )	BDBM50168995 ((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...) Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O |r| Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Newcastle University Curated by ChEMBL					Assay Description Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 2199 assessed as reduction of mannose release using 4NP-mannopyranoside substrate				Nat Chem Biol 6: 125-32 (2010) Article DOI: 10.1038/nchembio.278 BindingDB Entry DOI: 10.7270/Q2ZW1PQB
					More data for this Ligand-Target Pair
Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform B (Drosophila melanogaster)	BDBM50168995 ((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...) Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O |r| Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Slovak Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of Drosophila melanogaster GM2b by spectrophotometry				Eur J Med Chem 46: 944-52 (2011) Article DOI: 10.1016/j.ejmech.2011.01.012 BindingDB Entry DOI: 10.7270/Q2MS3TQM
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50168995 ((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...) Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O |r| Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.15E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Inhibition of HIV1 RT				J Nat Prod 54: 143-54 Article DOI: 10.1021/np50073a012 BindingDB Entry DOI: 10.7270/Q2NK3HTG
					More data for this Ligand-Target Pair
Lysosomal alpha-mannosidase (Homo sapiens (Human))	BDBM50168995 ((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...) Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O |r| Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Ecole Polytechnique Fédérale de Lausanne Curated by ChEMBL					Assay Description Inhibition of alpha-mannosidase in human LN18 cells				Bioorg Med Chem 16: 7337-46 (2008) Article DOI: 10.1016/j.bmc.2008.06.021 BindingDB Entry DOI: 10.7270/Q2668D0J
					More data for this Ligand-Target Pair
Lysosomal alpha-mannosidase (Homo sapiens (Human))	BDBM50168995 ((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...) Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O |r| Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ecole Polytechnique Fédérale de Lausanne Curated by ChEMBL					Assay Description Inhibition of alpha-mannosidase in human LNZ308 cells				Bioorg Med Chem 16: 7337-46 (2008) Article DOI: 10.1016/j.bmc.2008.06.021 BindingDB Entry DOI: 10.7270/Q2668D0J
					More data for this Ligand-Target Pair
Alpha-mannosidase (Glycine max)	BDBM50168995 ((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...) Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O |r| Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Chemical Sciences and Engineering Curated by ChEMBL					Assay Description Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean				J Med Chem 48: 4237-46 (2005) Article DOI: 10.1021/jm0409019 BindingDB Entry DOI: 10.7270/Q24J0DNV
					More data for this Ligand-Target Pair
Lysosomal alpha-mannosidase (Homo sapiens (Human))	BDBM50168995 ((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...) Show SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O |r| Show InChI InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Ecole Polytechnique Fédérale de Lausanne Curated by ChEMBL					Assay Description Inhibition of alpha-mannosidase in human HCEC				Bioorg Med Chem 16: 7337-46 (2008) Article DOI: 10.1016/j.bmc.2008.06.021 BindingDB Entry DOI: 10.7270/Q2668D0J
					More data for this Ligand-Target Pair