BDBM50169428 CHEMBL3805875::US9481677, 36

SMILES: Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ncc2cnccn12)S(=O)(=O)Nc1ncns1

InChI Key: InChIKey=XQGSUSFVPPFJIO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50169428   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50169428 (CHEMBL3805875 | US9481677, 36) Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ncc2cnccn12)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C20H11ClF2N6O3S2/c21-11-1-2-16(13(5-11)19-25-9-12-8-24-3-4-29(12)19)32-17-6-15(23)18(7-14(17)22)34(30,31)28-20-26-10-27-33-20/h1-10H,(H,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by...				ACS Med Chem Lett 7: 277-82 (2016) BindingDB Entry DOI: 10.7270/Q2J1052W
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM50169428 (CHEMBL3805875 | US9481677, 36) Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ncc2cnccn12)S(=O)(=O)Nc1ncns1 Show InChI InChI=1S/C20H11ClF2N6O3S2/c21-11-1-2-16(13(5-11)19-25-9-12-8-24-3-4-29(12)19)32-17-6-15(23)18(7-14(17)22)34(30,31)28-20-26-10-27-33-20/h1-10H,(H,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...				US Patent US9481677 (2016) BindingDB Entry DOI: 10.7270/Q20V8BQT
					More data for this Ligand-Target Pair