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BDBM50169428 CHEMBL3805875::US9481677, 36

SMILES: Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ncc2cnccn12)S(=O)(=O)Nc1ncns1

InChI Key: InChIKey=XQGSUSFVPPFJIO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50169428   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169428
PNG
(CHEMBL3805875 | US9481677, 36)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ncc2cnccn12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H11ClF2N6O3S2/c21-11-1-2-16(13(5-11)19-25-9-12-8-24-3-4-29(12)19)32-17-6-15(23)18(7-14(17)22)34(30,31)28-20-26-10-27-33-20/h1-10H,(H,26,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 2.30E+3n/an/an/an/an/an/a



Xenon Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by...


ACS Med Chem Lett 7: 277-82 (2016)


BindingDB Entry DOI: 10.7270/Q2J1052W
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50169428
PNG
(CHEMBL3805875 | US9481677, 36)
Show SMILES Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ncc2cnccn12)S(=O)(=O)Nc1ncns1
Show InChI InChI=1S/C20H11ClF2N6O3S2/c21-11-1-2-16(13(5-11)19-25-9-12-8-24-3-4-29(12)19)32-17-6-15(23)18(7-14(17)22)34(30,31)28-20-26-10-27-33-20/h1-10H,(H,26,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
US Patent
n/an/a 2.31E+3n/an/an/an/an/an/a



XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...


US Patent US9481677 (2016)


BindingDB Entry DOI: 10.7270/Q20V8BQT
More data for this
Ligand-Target Pair