BDBM50169433 CHEMBL3805201::US9481677, 58
SMILES: Nc1noc2ccc(cc12)-c1ccccc1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ncns1
InChI Key: InChIKey=RSNMSLWCZGKIHM-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50169433 (CHEMBL3805201 | US9481677, 58) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by... | ACS Med Chem Lett 7: 277-82 (2016) BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50169433 (CHEMBL3805201 | US9481677, 58) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
XENON PHARMACEUTICALS INC. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and... | US Patent US9481677 (2016) BindingDB Entry DOI: 10.7270/Q20V8BQT | |||||||||||
More data for this Ligand-Target Pair |