BDBM50171523 (4,5-Dichloro-2-fluoro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine::CHEMBL437879

SMILES: COc1cc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2cc1OC

InChI Key: InChIKey=AWSNTTSKWKZQQT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50171523   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50171523 ((4,5-Dichloro-2-fluoro-phenyl)-(6,7-dimethoxy-quin...) Show SMILES COc1cc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2cc1OC Show InChI InChI=1S/C16H12Cl2FN3O2/c1-23-14-3-8-12(6-15(14)24-2)20-7-21-16(8)22-13-5-10(18)9(17)4-11(13)19/h3-7H,1-2H3,(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
Hadassah Hebrew University Curated by ChEMBL					Assay Description Inhibition of EGF Receptor autophosphorylation in A431 cell lysate				J Med Chem 48: 5337-48 (2005) Article DOI: 10.1021/jm0580196 BindingDB Entry DOI: 10.7270/Q28S4PG3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50171523 ((4,5-Dichloro-2-fluoro-phenyl)-(6,7-dimethoxy-quin...) Show SMILES COc1cc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2cc1OC Show InChI InChI=1S/C16H12Cl2FN3O2/c1-23-14-3-8-12(6-15(14)24-2)20-7-21-16(8)22-13-5-10(18)9(17)4-11(13)19/h3-7H,1-2H3,(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Hadassah Hebrew University Curated by ChEMBL					Assay Description Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 3-5 nM				J Med Chem 48: 5337-48 (2005) Article DOI: 10.1021/jm0580196 BindingDB Entry DOI: 10.7270/Q28S4PG3
					More data for this Ligand-Target Pair