BDBM50171525 2-Chloro-N-[4-(3-iodo-phenylamino)-quinazolin-6-yl]-acetamide::CHEMBL193160
SMILES: ClCC(=O)Nc1ccc2ncnc(Nc3cccc(I)c3)c2c1
InChI Key: InChIKey=LANYSJQMFCSMRS-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50171525 (2-Chloro-N-[4-(3-iodo-phenylamino)-quinazolin-6-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Curated by ChEMBL | Assay Description Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 4-10 nM | J Med Chem 48: 5337-48 (2005) Article DOI: 10.1021/jm0580196 BindingDB Entry DOI: 10.7270/Q28S4PG3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50171525 (2-Chloro-N-[4-(3-iodo-phenylamino)-quinazolin-6-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Curated by ChEMBL | Assay Description Inhibition of EGF Receptor autophosphorylation in A431 cell lysate | J Med Chem 48: 5337-48 (2005) Article DOI: 10.1021/jm0580196 BindingDB Entry DOI: 10.7270/Q28S4PG3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50171525 (2-Chloro-N-[4-(3-iodo-phenylamino)-quinazolin-6-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Curated by ChEMBL | Assay Description Inhibition of EGF Receptor autophosphorylation in A431 cell lysate | J Med Chem 48: 5337-48 (2005) Article DOI: 10.1021/jm0580196 BindingDB Entry DOI: 10.7270/Q28S4PG3 | |||||||||||
More data for this Ligand-Target Pair |