BDBM50171801 CHEMBL198367::N-[4-(5-Bromo-6-hydroxy-naphthalen-1-yl)-3,5-dichloro-phenyl]-oxalamic acid
SMILES: OC(=O)C(=O)Nc1cc(Cl)c(c(Cl)c1)-c1cccc2c(Br)c(O)ccc12
InChI Key: InChIKey=BPNAEYPMWGNDGQ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thyroid hormone receptor alpha (Homo sapiens (Human)) | BDBM50171801 (CHEMBL198367 | N-[4-(5-Bromo-6-hydroxy-naphthalen-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibitory concentration against cloned human thyroid hormone receptor alpha 1 | Bioorg Med Chem Lett 15: 4579-84 (2005) Article DOI: 10.1016/j.bmcl.2005.06.093 BindingDB Entry DOI: 10.7270/Q2GB23MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50171801 (CHEMBL198367 | N-[4-(5-Bromo-6-hydroxy-naphthalen-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibitory concentration against cloned human thyroid hormone receptor beta 1 | Bioorg Med Chem Lett 15: 4579-84 (2005) Article DOI: 10.1016/j.bmcl.2005.06.093 BindingDB Entry DOI: 10.7270/Q2GB23MG | |||||||||||
More data for this Ligand-Target Pair |