BDBM50171802 CHEMBL196642::N-[3,5-Dichloro-4-(5-isopropyl-6-methoxy-naphthalen-1-yl)-phenyl]-malonamic acid
SMILES: COc1ccc2c(cccc2c1C(C)C)-c1c(Cl)cc(NC(=O)CC(O)=O)cc1Cl
InChI Key: InChIKey=ZJBJLVZJXUYGMP-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thyroid hormone receptor alpha (Homo sapiens (Human)) | BDBM50171802 (CHEMBL196642 | N-[3,5-Dichloro-4-(5-isopropyl-6-me...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibitory concentration against cloned human thyroid hormone receptor alpha 1 | Bioorg Med Chem Lett 15: 4579-84 (2005) Article DOI: 10.1016/j.bmcl.2005.06.093 BindingDB Entry DOI: 10.7270/Q2GB23MG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid hormone receptor beta (Homo sapiens (Human)) | BDBM50171802 (CHEMBL196642 | N-[3,5-Dichloro-4-(5-isopropyl-6-me...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibitory concentration against cloned human thyroid hormone receptor beta 1 | Bioorg Med Chem Lett 15: 4579-84 (2005) Article DOI: 10.1016/j.bmcl.2005.06.093 BindingDB Entry DOI: 10.7270/Q2GB23MG | |||||||||||
More data for this Ligand-Target Pair |