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SMILES: Clc1cccc(c1)C1CC(=NN1c1ccccc1)c1ccc2OCCOc2c1

InChI Key: InChIKey=LYQWMJNCMLZNBS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50172060   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50172060 (CHEMBL3805409) Show SMILES Clc1cccc(c1)C1CC(=NN1c1ccccc1)c1ccc2OCCOc2c1 |c:10| Show InChI InChI=1S/C23H19ClN2O2/c24-18-6-4-5-17(13-18)21-15-20(25-26(21)19-7-2-1-3-8-19)16-9-10-22-23(14-16)28-12-11-27-22/h1-10,13-14,21H,11-12,15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8.12E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of recombinant His6-tagged EGFR (unknown origin) cytoplasmic domain (645 to 1186 residues) autophosphorylation expressed in baculovirus in...				Bioorg Med Chem 24: 3052-3061 (2016) BindingDB Entry DOI: 10.7270/Q2HX1FKZ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Mus musculus)	BDBM50172060 (CHEMBL3805409) Show SMILES Clc1cccc(c1)C1CC(=NN1c1ccccc1)c1ccc2OCCOc2c1 |c:10| Show InChI InChI=1S/C23H19ClN2O2/c24-18-6-4-5-17(13-18)21-15-20(25-26(21)19-7-2-1-3-8-19)16-9-10-22-23(14-16)28-12-11-27-22/h1-10,13-14,21H,11-12,15H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.83E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of mouse wild type BRAF assessed as reduction in human full length N-terminal His-tagged MEK1 phosphorylation pre-incubated for 1 hr befor...				Bioorg Med Chem 24: 3052-3061 (2016) BindingDB Entry DOI: 10.7270/Q2HX1FKZ
					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Mus musculus)	BDBM50172060 (CHEMBL3805409) Show SMILES Clc1cccc(c1)C1CC(=NN1c1ccccc1)c1ccc2OCCOc2c1 |c:10| Show InChI InChI=1S/C23H19ClN2O2/c24-18-6-4-5-17(13-18)21-15-20(25-26(21)19-7-2-1-3-8-19)16-9-10-22-23(14-16)28-12-11-27-22/h1-10,13-14,21H,11-12,15H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.46E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of mouse c-Raf assessed as reduction in human full length N-terminal His-tagged MEK1 phosphorylation pre-incubated for 1 hr before MEK1 ad...				Bioorg Med Chem 24: 3052-3061 (2016) BindingDB Entry DOI: 10.7270/Q2HX1FKZ
					More data for this Ligand-Target Pair