BDBM50172241 CHEMBL3810168::US10294221, Example 22(a)
SMILES: CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cncnn2)s1)c1cccc(OC(F)(F)F)c1
InChI Key: InChIKey=MIVIOHXOLBNSSV-IUODEOHRSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM50172241 (CHEMBL3810168 | US10294221, Example 22(a)) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Inhibition of 6His-tagged GLS1 (63-669 residues) (unknown origin) expressed in Escherichia coli using glutamine as substrate after 15 mins by Glutama... | ACS Med Chem Lett 7: 207-8 (2016) BindingDB Entry DOI: 10.7270/Q2GX4DG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM50172241 (CHEMBL3810168 | US10294221, Example 22(a)) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 72.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM50172241 (CHEMBL3810168 | US10294221, Example 22(a)) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.206 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Inhibition of GLS1 in human PC3 cells assessed as cellular glutamate depletion levels after 6 hrs by Glutamate Oxidase/ AmplexRed coupled assay | ACS Med Chem Lett 7: 207-8 (2016) BindingDB Entry DOI: 10.7270/Q2GX4DG1 | |||||||||||
More data for this Ligand-Target Pair |