BDBM50172340 1-[1-(5-Methoxy-2,2-dimethyl-2H-chromen-6-yl)-ethyl]-1H-imidazo[4,5-b]pyridine::CHEMBL424830
SMILES: COc1c(ccc2OC(C)(C)C=Cc12)C(C)n1cnc2ncccc12
InChI Key: InChIKey=MCVWPJZBARCDLJ-UHFFFAOYSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human)) | BDBM50172340 (1-[1-(5-Methoxy-2,2-dimethyl-2H-chromen-6-yl)-ethy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a |
The Scripps Research Institute Curated by ChEMBL | Assay Description Effective concentration to inhibit production of hypoxia inducible factor 1-alpha protein | J Med Chem 48: 5613-38 (2005) Article DOI: 10.1021/jm050524f BindingDB Entry DOI: 10.7270/Q2V988V1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human)) | BDBM50172340 (1-[1-(5-Methoxy-2,2-dimethyl-2H-chromen-6-yl)-ethy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a |
The Scripps Research Institute Curated by ChEMBL | Assay Description Effective concentration to inhibit production of hypoxia inducible factor 1-alpha protein | J Med Chem 48: 5613-38 (2005) Article DOI: 10.1021/jm050524f BindingDB Entry DOI: 10.7270/Q2V988V1 | |||||||||||
More data for this Ligand-Target Pair |