BDBM50172426 (E)-N-[2-(2-Dimethylamino-1-methyl-ethylamino)-4-methyl-quinolin-6-yl]-3-(4-trifluoromethoxy-phenyl)-acrylamide::CHEMBL194046

SMILES: CC(CN(C)C)Nc1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1

InChI Key: InChIKey=VHJCFOPANRJFEX-KPKJPENVSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50172426   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50172426 ((E)-N-[2-(2-Dimethylamino-1-methyl-ethylamino)-4-m...) Show SMILES CC(CN(C)C)Nc1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1 Show InChI InChI=1S/C25H27F3N4O2/c1-16-13-23(29-17(2)15-32(3)4)31-22-11-8-19(14-21(16)22)30-24(33)12-7-18-5-9-20(10-6-18)34-25(26,27)28/h5-14,17H,15H2,1-4H3,(H,29,31)(H,30,33)/b12-7+	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assay				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50172426 ((E)-N-[2-(2-Dimethylamino-1-methyl-ethylamino)-4-m...) Show SMILES CC(CN(C)C)Nc1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1 Show InChI InChI=1S/C25H27F3N4O2/c1-16-13-23(29-17(2)15-32(3)4)31-22-11-8-19(14-21(16)22)30-24(33)12-7-18-5-9-20(10-6-18)34-25(26,27)28/h5-14,17H,15H2,1-4H3,(H,29,31)(H,30,33)/b12-7+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Inhibitory concentration against human 5-hydroxytryptamine 2C receptor expressed in CHO-K1 cells using [3H]-mesulergine				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50172426 ((E)-N-[2-(2-Dimethylamino-1-methyl-ethylamino)-4-m...) Show SMILES CC(CN(C)C)Nc1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1 Show InChI InChI=1S/C25H27F3N4O2/c1-16-13-23(29-17(2)15-32(3)4)31-22-11-8-19(14-21(16)22)30-24(33)12-7-18-5-9-20(10-6-18)34-25(26,27)28/h5-14,17H,15H2,1-4H3,(H,29,31)(H,30,33)/b12-7+	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50172426 ((E)-N-[2-(2-Dimethylamino-1-methyl-ethylamino)-4-m...) Show SMILES CC(CN(C)C)Nc1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1 Show InChI InChI=1S/C25H27F3N4O2/c1-16-13-23(29-17(2)15-32(3)4)31-22-11-8-19(14-21(16)22)30-24(33)12-7-18-5-9-20(10-6-18)34-25(26,27)28/h5-14,17H,15H2,1-4H3,(H,29,31)(H,30,33)/b12-7+	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositol				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair