BDBM50172428 (E)-N-[2-((3S,5R)-3,5-Dimethyl-piperazin-1-yl)-4-methyl-quinolin-6-yl]-3-(4-trifluoromethoxy-phenyl)-acrylamide::CHEMBL195250

SMILES: C[C@H]1CN(C[C@@H](C)N1)c1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1

InChI Key: InChIKey=DVNOJAJYFIOGBD-SEKNRTTHSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50172428   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50172428 ((E)-N-[2-((3S,5R)-3,5-Dimethyl-piperazin-1-yl)-4-m...) Show SMILES C[C@H]1CN(C[C@@H](C)N1)c1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1 Show InChI InChI=1S/C26H27F3N4O2/c1-16-12-24(33-14-17(2)30-18(3)15-33)32-23-10-7-20(13-22(16)23)31-25(34)11-6-19-4-8-21(9-5-19)35-26(27,28)29/h4-13,17-18,30H,14-15H2,1-3H3,(H,31,34)/b11-6+/t17-,18+	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositol				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50172428 ((E)-N-[2-((3S,5R)-3,5-Dimethyl-piperazin-1-yl)-4-m...) Show SMILES C[C@H]1CN(C[C@@H](C)N1)c1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1 Show InChI InChI=1S/C26H27F3N4O2/c1-16-12-24(33-14-17(2)30-18(3)15-33)32-23-10-7-20(13-22(16)23)31-25(34)11-6-19-4-8-21(9-5-19)35-26(27,28)29/h4-13,17-18,30H,14-15H2,1-3H3,(H,31,34)/b11-6+/t17-,18+	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assay				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50172428 ((E)-N-[2-((3S,5R)-3,5-Dimethyl-piperazin-1-yl)-4-m...) Show SMILES C[C@H]1CN(C[C@@H](C)N1)c1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1 Show InChI InChI=1S/C26H27F3N4O2/c1-16-12-24(33-14-17(2)30-18(3)15-33)32-23-10-7-20(13-22(16)23)31-25(34)11-6-19-4-8-21(9-5-19)35-26(27,28)29/h4-13,17-18,30H,14-15H2,1-3H3,(H,31,34)/b11-6+/t17-,18+	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	409	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair