BDBM50172438 CHEMBL194691::N-{2-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-4-methyl-quinolin-6-yl}-2-(4-trifluoromethoxy-phenoxy)-acetamide

SMILES: CCN1CCCC1CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1

InChI Key: InChIKey=WTECJAHWHNJGGJ-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50172438   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50172438 (CHEMBL194691 | N-{2-[(1-Ethyl-pyrrolidin-2-ylmethy...) Show SMILES CCN1CCCC1CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1 Show InChI InChI=1S/C26H29F3N4O3/c1-3-33-12-4-5-19(33)15-30-24-13-17(2)22-14-18(6-11-23(22)32-24)31-25(34)16-35-20-7-9-21(10-8-20)36-26(27,28)29/h6-11,13-14,19H,3-5,12,15-16H2,1-2H3,(H,30,32)(H,31,34)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair
GPR145 (Homo sapiens (Human))	BDBM50172438 (CHEMBL194691 | N-{2-[(1-Ethyl-pyrrolidin-2-ylmethy...) Show SMILES CCN1CCCC1CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1 Show InChI InChI=1S/C26H29F3N4O3/c1-3-33-12-4-5-19(33)15-30-24-13-17(2)22-14-18(6-11-23(22)32-24)31-25(34)16-35-20-7-9-21(10-8-20)36-26(27,28)29/h6-11,13-14,19H,3-5,12,15-16H2,1-2H3,(H,30,32)(H,31,34)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>10	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50172438 (CHEMBL194691 | N-{2-[(1-Ethyl-pyrrolidin-2-ylmethy...) Show SMILES CCN1CCCC1CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1 Show InChI InChI=1S/C26H29F3N4O3/c1-3-33-12-4-5-19(33)15-30-24-13-17(2)22-14-18(6-11-23(22)32-24)31-25(34)16-35-20-7-9-21(10-8-20)36-26(27,28)29/h6-11,13-14,19H,3-5,12,15-16H2,1-2H3,(H,30,32)(H,31,34)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Inhibitory concentration against human 5-hydroxytryptamine 2C receptor expressed in CHO-K1 cells using [3H]-mesulergine				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50172438 (CHEMBL194691 | N-{2-[(1-Ethyl-pyrrolidin-2-ylmethy...) Show SMILES CCN1CCCC1CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1 Show InChI InChI=1S/C26H29F3N4O3/c1-3-33-12-4-5-19(33)15-30-24-13-17(2)22-14-18(6-11-23(22)32-24)31-25(34)16-35-20-7-9-21(10-8-20)36-26(27,28)29/h6-11,13-14,19H,3-5,12,15-16H2,1-2H3,(H,30,32)(H,31,34)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assay				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50172438 (CHEMBL194691 | N-{2-[(1-Ethyl-pyrrolidin-2-ylmethy...) Show SMILES CCN1CCCC1CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1 Show InChI InChI=1S/C26H29F3N4O3/c1-3-33-12-4-5-19(33)15-30-24-13-17(2)22-14-18(6-11-23(22)32-24)31-25(34)16-35-20-7-9-21(10-8-20)36-26(27,28)29/h6-11,13-14,19H,3-5,12,15-16H2,1-2H3,(H,30,32)(H,31,34)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	109	n/a	n/a	n/a	n/a	n/a	n/a
7TM Pharma A/S Curated by ChEMBL					Assay Description Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositol				J Med Chem 48: 5684-97 (2005) Article DOI: 10.1021/jm050103y BindingDB Entry DOI: 10.7270/Q2H41QZ8
					More data for this Ligand-Target Pair