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SMILES: CC(C(O)=O)c1ccc(c(F)c1)-c1ccc(OC2CCCCC2)cc1

InChI Key: InChIKey=JSVKMROCBOUOTF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50172474   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Amyloid-beta precursor protein


(Homo sapiens (Human))		BDBM50172474
PNG
(2-(4'-Cyclohexyloxy-2-fluoro-biphenyl-4-yl)-propio...)
Show SMILES CC(C(O)=O)c1ccc(c(F)c1)-c1ccc(OC2CCCCC2)cc1
Show InChI InChI=1S/C21H23FO3/c1-14(21(23)24)16-9-12-19(20(22)13-16)15-7-10-18(11-8-15)25-17-5-3-2-4-6-17/h7-14,17H,2-6H2,1H3,(H,23,24)
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n/an/a 4.10E+4n/an/an/an/an/an/a



Chiesi Farmaceutici S.p.A.

Curated by ChEMBL


Assay Description
Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)

J Med Chem 48: 5705-20 (2005)


Article DOI: 10.1021/jm0502541
BindingDB Entry DOI: 10.7270/Q2CC106W
More data for this
Ligand-Target Pair