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BDBM50172478 2-(3',5'-Dichloro-2-fluoro-biphenyl-4-yl)-propionic acid tert-butyl ester::CHEMBL194020

SMILES: CC(C(=O)OC(C)(C)C)c1ccc(c(F)c1)-c1cc(Cl)cc(Cl)c1

InChI Key: InChIKey=TVDXFZAFRUSAOI-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50172478   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta amyloid A4 protein


(Homo sapiens (Human))
BDBM50172478
PNG
(2-(3',5'-Dichloro-2-fluoro-biphenyl-4-yl)-propioni...)
Show SMILES CC(C(=O)OC(C)(C)C)c1ccc(c(F)c1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C19H19Cl2FO2/c1-11(18(23)24-19(2,3)4)12-5-6-16(17(22)9-12)13-7-14(20)10-15(21)8-13/h5-11H,1-4H3
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



Chiesi Farmaceutici S.p.A.

Curated by ChEMBL


Assay Description
Concentration required to inhibit A beta 40 peptide 100 uM


J Med Chem 48: 5705-20 (2005)


Article DOI: 10.1021/jm0502541
BindingDB Entry DOI: 10.7270/Q2CC106W
More data for this
Ligand-Target Pair