BDBM50172483 2-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-propionic acid::CHEMBL196279

SMILES: CC(C(O)=O)c1ccc(c(F)c1)-c1ccc(Cl)c(Cl)c1

InChI Key: InChIKey=PGOBYHDWDSAXMB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50172483   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta amyloid A4 protein (Homo sapiens (Human))	BDBM50172483 (2-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-propioni...) Show SMILES CC(C(O)=O)c1ccc(c(F)c1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C15H11Cl2FO2/c1-8(15(19)20)9-2-4-11(14(18)7-9)10-3-5-12(16)13(17)6-10/h2-8H,1H3,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chiesi Farmaceutici S.p.A. Curated by ChEMBL					Assay Description Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)				J Med Chem 48: 5705-20 (2005) Article DOI: 10.1021/jm0502541 BindingDB Entry DOI: 10.7270/Q2CC106W
					More data for this Ligand-Target Pair