BDBM50173019 4-(4-(4-tert-butylphenylamino)phthalazin-1-yl)benzamide::4-[4-(4-tert-Butyl-phenylamino)-phthalazin-1-yl]-benzamide::CHEMBL370586::IM-094261
SMILES: CC(C)(C)c1ccc(Nc2nnc(-c3ccc(cc3)C(N)=O)c3ccccc23)cc1
InChI Key: InChIKey=FIQNADOCRLODMD-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50173019 (4-(4-(4-tert-butylphenylamino)phthalazin-1-yl)benz...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc. Curated by ChEMBL | Assay Description Inhibition of VEGFR2 (unknown origin) by HTRF method | Bioorg Med Chem 17: 731-40 (2009) Article DOI: 10.1016/j.bmc.2008.11.049 BindingDB Entry DOI: 10.7270/Q2W95929 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50173019 (4-(4-(4-tert-butylphenylamino)phthalazin-1-yl)benz...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems Curated by ChEMBL | Assay Description Inhibition of Vascular endothelial growth factor receptor 2 kinase phosphorylation of pGAT-biotin peptide | Bioorg Med Chem Lett 15: 4696-8 (2005) Article DOI: 10.1016/j.bmcl.2005.07.064 BindingDB Entry DOI: 10.7270/Q25Q4VNS | |||||||||||
More data for this Ligand-Target Pair |