BDBM50173249 CHEMBL197880::methyl 2-[2-oxo-1'-(4-trifluoromethylbenzyl)spiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]acetate

SMILES: COC(=O)CN1C(=O)C2(CCN(Cc3ccc(cc3)C(F)(F)F)CC2)c2ccccc12

InChI Key: InChIKey=DCWFNQNFMSENOI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173249   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50173249 (CHEMBL197880 | methyl 2-[2-oxo-1'-(4-trifluorometh...) Show SMILES COC(=O)CN1C(=O)C2(CCN(Cc3ccc(cc3)C(F)(F)F)CC2)c2ccccc12 Show InChI InChI=1S/C23H23F3N2O3/c1-31-20(29)15-28-19-5-3-2-4-18(19)22(21(28)30)10-12-27(13-11-22)14-16-6-8-17(9-7-16)23(24,25)26/h2-9H,10-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair