BDBM50173279 CHEMBL383561::methyl [1'-(cyclopropylmethyl)-2-oxospiro[indole-3,4'-piperidin]-1(2H)-yl]acetate

SMILES: COC(=O)CN1C(=O)C2(CCN(CC3CC3)CC2)c2ccccc12

InChI Key: InChIKey=FNAPUUOMTUXUGT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173279   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50173279 (CHEMBL383561 | methyl [1'-(cyclopropylmethyl)-2-ox...) Show SMILES COC(=O)CN1C(=O)C2(CCN(CC3CC3)CC2)c2ccccc12 Show InChI InChI=1S/C19H24N2O3/c1-24-17(22)13-21-16-5-3-2-4-15(16)19(18(21)23)8-10-20(11-9-19)12-14-6-7-14/h2-5,14H,6-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity determined by the ability to compete with [125I]-Tyr14- nociceptin from binding to human opiate receptor-like 1 expressed in HEK293 ...				Bioorg Med Chem Lett 15: 5022-6 (2005) Article DOI: 10.1016/j.bmcl.2005.08.009 BindingDB Entry DOI: 10.7270/Q2RF5TKC
					More data for this Ligand-Target Pair