BDBM50173327 CHEMBL3808499::US10023564, Example 28
SMILES: CC1=C(C(NC(=O)N1)c1ccc(F)c(CC(=O)NCc2c(C)cccc2C)c1)C(=O)Nc1ccc2[nH]ncc2c1
InChI Key: InChIKey=IDOAXNXBZZZOFX-UHFFFAOYSA-N
Data: 7 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G protein-coupled receptor kinase 5 (Homo sapiens (Human)) | BDBM50173327 (CHEMBL3808499 | US10023564, Example 28) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 8.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University Curated by ChEMBL | Assay Description Inhibition of GRK5 (unknown origin) using tubulin as substrate by SDS-PAGE method | J Med Chem 59: 3793-807 (2016) BindingDB Entry DOI: 10.7270/Q2JQ12X4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhodopsin kinase (Homo sapiens (Human)) | BDBM50173327 (CHEMBL3808499 | US10023564, Example 28) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University Curated by ChEMBL | Assay Description Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE method | J Med Chem 59: 3793-807 (2016) BindingDB Entry DOI: 10.7270/Q2JQ12X4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM50173327 (CHEMBL3808499 | US10023564, Example 28) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University Curated by ChEMBL | Assay Description Inhibition of ROCK1 (unknown origin) by ADP-Glo kinase assay | J Med Chem 59: 3793-807 (2016) BindingDB Entry DOI: 10.7270/Q2JQ12X4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM50173327 (CHEMBL3808499 | US10023564, Example 28) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &... | US Patent US10023564 (2018) BindingDB Entry DOI: 10.7270/Q2V126V5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-adrenergic receptor kinase 1 (Homo sapiens (Human)) | BDBM50173327 (CHEMBL3808499 | US10023564, Example 28) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e... | US Patent US10023564 (2018) BindingDB Entry DOI: 10.7270/Q2V126V5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor kinase 5 (Homo sapiens (Human)) | BDBM50173327 (CHEMBL3808499 | US10023564, Example 28) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.0 | n/a |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e... | US Patent US10023564 (2018) BindingDB Entry DOI: 10.7270/Q2V126V5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rhodopsin kinase (Homo sapiens (Human)) | BDBM50173327 (CHEMBL3808499 | US10023564, Example 28) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.0 | n/a |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e... | US Patent US10023564 (2018) BindingDB Entry DOI: 10.7270/Q2V126V5 | |||||||||||
More data for this Ligand-Target Pair |