BDBM50173530 1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione::CHEMBL370768::dUTPase inhibitor, 9

SMILES: CC(C)(C)[Si](OCC1OC(CC1O)n1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1

InChI Key: InChIKey=ITTZDQXTFVFANF-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50173530   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
dUTP pyrophosphatase (Plasmodium falciparum)	BDBM50173530 (1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydr...) Show SMILES CC(C)(C)[Si](OCC1OC(CC1O)n1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H30N2O5Si/c1-25(2,3)33(18-10-6-4-7-11-18,19-12-8-5-9-13-19)31-17-21-20(28)16-23(32-21)27-15-14-22(29)26-24(27)30/h4-15,20-21,23,28H,16-17H2,1-3H3,(H,26,29,30)	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.20E+3	-7.33	n/a	n/a	n/a	n/a	n/a	8.0	25
Instituto de Parastiologia y Biomedicina "Lopez-Neyra"					Assay Description Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...				J Enzyme Inhib Med Chem 24: 111-6 (2009) Article DOI: 10.1080/14756360801915476 BindingDB Entry DOI: 10.7270/Q2JH3JST
					More data for this Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (Homo sapiens (Human))	BDBM50173530 (1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydr...) Show SMILES CC(C)(C)[Si](OCC1OC(CC1O)n1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H30N2O5Si/c1-25(2,3)33(18-10-6-4-7-11-18,19-12-8-5-9-13-19)31-17-21-20(28)16-23(32-21)27-15-14-22(29)26-24(27)30/h4-15,20-21,23,28H,16-17H2,1-3H3,(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.05E+5	-4.22	n/a	n/a	n/a	n/a	n/a	8.0	25
Instituto de Parastiologia y Biomedicina "Lopez-Neyra"					Assay Description Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...				J Enzyme Inhib Med Chem 24: 111-6 (2009) Article DOI: 10.1080/14756360801915476 BindingDB Entry DOI: 10.7270/Q2JH3JST
					More data for this Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (Campylobacter jejuni)	BDBM50173530 (1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydr...) Show SMILES CC(C)(C)[Si](OCC1OC(CC1O)n1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H30N2O5Si/c1-25(2,3)33(18-10-6-4-7-11-18,19-12-8-5-9-13-19)31-17-21-20(28)16-23(32-21)27-15-14-22(29)26-24(27)30/h4-15,20-21,23,28H,16-17H2,1-3H3,(H,26,29,30)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.00E+9	0	n/a	n/a	n/a	n/a	n/a	8.0	25
Instituto de Parastiologia y Biomedicina "Lopez-Neyra"					Assay Description Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...				J Enzyme Inhib Med Chem 24: 111-6 (2009) Article DOI: 10.1080/14756360801915476 BindingDB Entry DOI: 10.7270/Q2JH3JST
					More data for this Ligand-Target Pair