BDBM50173531 1-(4-Hydroxy-5-triphenylsilanyloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione::CHEMBL197290::dUTPase inhibitor, 8

SMILES: OC1CC(OC1CO[Si](c1ccccc1)(c1ccccc1)c1ccccc1)n1ccc(=O)[nH]c1=O

InChI Key: InChIKey=HEOOHGVQTWVRSR-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50173531   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
dUTP pyrophosphatase (Plasmodium falciparum)	BDBM50173531 (1-(4-Hydroxy-5-triphenylsilanyloxymethyl-tetrahydr...) Show SMILES OC1CC(OC1CO[Si](c1ccccc1)(c1ccccc1)c1ccccc1)n1ccc(=O)[nH]c1=O Show InChI InChI=1S/C27H26N2O5Si/c30-23-18-26(29-17-16-25(31)28-27(29)32)34-24(23)19-33-35(20-10-4-1-5-11-20,21-12-6-2-7-13-21)22-14-8-3-9-15-22/h1-17,23-24,26,30H,18-19H2,(H,28,31,32)	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80E+3	-7.57	n/a	n/a	n/a	n/a	n/a	8.0	25
Instituto de Parastiologia y Biomedicina "Lopez-Neyra"					Assay Description Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...				J Enzyme Inhib Med Chem 24: 111-6 (2009) Article DOI: 10.1080/14756360801915476 BindingDB Entry DOI: 10.7270/Q2JH3JST
					More data for this Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (Homo sapiens (Human))	BDBM50173531 (1-(4-Hydroxy-5-triphenylsilanyloxymethyl-tetrahydr...) Show SMILES OC1CC(OC1CO[Si](c1ccccc1)(c1ccccc1)c1ccccc1)n1ccc(=O)[nH]c1=O Show InChI InChI=1S/C27H26N2O5Si/c30-23-18-26(29-17-16-25(31)28-27(29)32)34-24(23)19-33-35(20-10-4-1-5-11-20,21-12-6-2-7-13-21)22-14-8-3-9-15-22/h1-17,23-24,26,30H,18-19H2,(H,28,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9.08E+5	-4.15	n/a	n/a	n/a	n/a	n/a	8.0	25
Instituto de Parastiologia y Biomedicina "Lopez-Neyra"					Assay Description Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...				J Enzyme Inhib Med Chem 24: 111-6 (2009) Article DOI: 10.1080/14756360801915476 BindingDB Entry DOI: 10.7270/Q2JH3JST
					More data for this Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (Campylobacter jejuni)	BDBM50173531 (1-(4-Hydroxy-5-triphenylsilanyloxymethyl-tetrahydr...) Show SMILES OC1CC(OC1CO[Si](c1ccccc1)(c1ccccc1)c1ccccc1)n1ccc(=O)[nH]c1=O Show InChI InChI=1S/C27H26N2O5Si/c30-23-18-26(29-17-16-25(31)28-27(29)32)34-24(23)19-33-35(20-10-4-1-5-11-20,21-12-6-2-7-13-21)22-14-8-3-9-15-22/h1-17,23-24,26,30H,18-19H2,(H,28,31,32)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.00E+9	0	n/a	n/a	n/a	n/a	n/a	8.0	25
Instituto de Parastiologia y Biomedicina "Lopez-Neyra"					Assay Description Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...				J Enzyme Inhib Med Chem 24: 111-6 (2009) Article DOI: 10.1080/14756360801915476 BindingDB Entry DOI: 10.7270/Q2JH3JST
					More data for this Ligand-Target Pair