BDBM50173647 (E)-4-(4-(methylamino)styryl)phenol::4-(4-(methylamino)styryl)phenol::4-N-methylamino-4'-hydroxystilbene::4-[(E)-2-(4-Methylamino-phenyl)-vinyl]-phenol::CHEMBL381642::SB-13::[3H]-4-(4-(methylamino)styryl)phenol
SMILES: CNc1ccc(\C=C\c2ccc(O)cc2)cc1
InChI Key: InChIKey=ZWIARAQZLULYPG-NSCUHMNNSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta amyloid A4 protein (Homo sapiens (Human)) | BDBM50173647 ((E)-4-(4-(methylamino)styryl)phenol | 4-(4-(methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description Inhibition constant for I-125-IMPY binding to amyloid plaques in Alzheimers disease brain homogenates | J Med Chem 48: 5980-8 (2005) Article DOI: 10.1021/jm050166g BindingDB Entry DOI: 10.7270/Q2TB17PR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (Human)) | BDBM50173647 ((E)-4-(4-(methylamino)styryl)phenol | 4-(4-(methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sungkyunkwan University School of Medicine Curated by ChEMBL | Assay Description Binding affinity to amyloid beta (1-42) aggregates in human Alzheimer's disease brain sections | J Med Chem 55: 883-92 (2012) Article DOI: 10.1021/jm201400q BindingDB Entry DOI: 10.7270/Q2X92F5G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (Human)) | BDBM50173647 ((E)-4-(4-(methylamino)styryl)phenol | 4-(4-(methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description Displacement of [125I]2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine from beta amyloid peptide in brain tissue at 50 uL | J Med Chem 49: 2841-4 (2006) Article DOI: 10.1021/jm051020k BindingDB Entry DOI: 10.7270/Q2Q23ZT9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (Human)) | BDBM50173647 ((E)-4-(4-(methylamino)styryl)phenol | 4-(4-(methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description Binding affinity to Beta amyloid aggregates in Alzheimer's disease patient brain by competitive binding assay | J Med Chem 53: 933-41 (2010) Article DOI: 10.1021/jm901039z BindingDB Entry DOI: 10.7270/Q2RX9FW6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (Human)) | BDBM50173647 ((E)-4-(4-(methylamino)styryl)phenol | 4-(4-(methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description Displacement of [18F]-amyvid from amyloid-beta aggregates in alzheimer's disease patient brain homogenates after 1 hr | J Med Chem 54: 8085-98 (2011) Article DOI: 10.1021/jm2009106 BindingDB Entry DOI: 10.7270/Q26976FJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (Human)) | BDBM50173647 ((E)-4-(4-(methylamino)styryl)phenol | 4-(4-(methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nagasaki University Curated by ChEMBL | Assay Description Binding affinity to beta amyloid in human corpse AD brain | J Med Chem 49: 2725-30 (2006) Article DOI: 10.1021/jm051176k BindingDB Entry DOI: 10.7270/Q23B5ZRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (Human)) | BDBM50173647 ((E)-4-(4-(methylamino)styryl)phenol | 4-(4-(methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description Displacement of [125I](E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)styrylbenzene from beta amyloid peptide in brain tissue at 50 uL | J Med Chem 49: 2841-4 (2006) Article DOI: 10.1021/jm051020k BindingDB Entry DOI: 10.7270/Q2Q23ZT9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (Human)) | BDBM50173647 ((E)-4-(4-(methylamino)styryl)phenol | 4-(4-(methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description Binding affinity to Beta amyloid aggregates in Alzheimer's disease patient brain | J Med Chem 53: 933-41 (2010) Article DOI: 10.1021/jm901039z BindingDB Entry DOI: 10.7270/Q2RX9FW6 | |||||||||||
More data for this Ligand-Target Pair |