BDBM50173826 1-[(S)-2-Amino-3-(3-methyl-3H-imidazol-4-yl)-propionyl]-5-oxo-pyrrolidine-2-carboxylic acid {2-((S)-2-carbamoyl-pyrrolidin-1-yl)-1-[(S)-1-(1H-imidazol-4-yl)methyl]-2-oxo-ethyl}-amide::CHEMBL365775
SMILES: Cn1cncc1C[C@H](N)C(=O)N1[C@@H](CCC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
InChI Key: InChIKey=WKQRLJGRLFCLNV-XSLAGTTESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thyrotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50173826 (1-[(S)-2-Amino-3-(3-methyl-3H-imidazol-4-yl)-propi...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degee C for 1 hr at pH 7.4 us... | J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50173826 (1-[(S)-2-Amino-3-(3-methyl-3H-imidazol-4-yl)-propi...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | 7.8 | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio... | J Med Chem 48: 6162-5 (2005) Article DOI: 10.1021/jm0505462 BindingDB Entry DOI: 10.7270/Q2PK0FQG | |||||||||||
More data for this Ligand-Target Pair |